Corrigendum: Zebrafish Models for Human Acute Organophosphorus Poisoning
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Zebrafish Models for Human Acute Organophosphorus Poisoning
Terrorist use of organophosphorus-based nerve agents and toxic industrial chemicals against civilian populations constitutes a real threat, as demonstrated by the terrorist attacks in Japan in the 1990 s or, even more recently, in the Syrian civil war. Thus, development of more effective countermeasures against acute organophosphorus poisoning is urgently needed. Here, we have generated and val...
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Zebrafish models for mild, moderate, and severe acute organophosphorus poisoning were previously developed by exposing zebrafish larvae to chlopyrifos-oxon. The phenotype of these models was characterized at several levels of biological organization. Oxidative stress and mitochondrial dysfunction were found to be involved in the development of the more severe phenotype. Here we used targeted ge...
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Background: Prolonged inhibition of acetylcholine esterase may lead to the intermediate syndrome. Neuromuscular junction (NMJ) dysfunction has been shown with repetitive nerve stimulation (RNS). Subclinical NMJ dysfunction may also occur. We aimed to examine the NMJ function following acute organophosphorus (OP) poisoning by using exercise modified slow RNS. Methods: A cohort study was conducte...
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Objective: Organophosphorus compounds (OPs) are common causes of poisonings. Atropine and oximes are pharmacological antidotes of OPs. However, because of their adverse effects and insufficient performance, several other compounds have been evaluated as adjuvant therapy. HESA-A is a herbal-marine drug that contains material from Carum carvi (Persian cumin), Penaeus latisculatus...
متن کاملCorrelation between Serum Creatine Phosphokinase and Severity of Acute Organophosphorus Poisoning: A Prospective Clinical Study (2012-2013)
Organophosphorus (OP) poisoning is an important global health problem especially in developing countries like Egypt. . Estimation of erythrocyte cholinesterase (EChE) and butyrylcholinesterase (BChE) as an evidence of OP poisoning is costly, not regularly performed and shows wide inter-individual variability. Therefore, this study was designed to assess if serum creatine phosphokinase (CPK) can...
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